AICAR

AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), also known as acadesine, is a small-molecule nucleoside analogue of adenosine monophosphate precursors. Although not a peptide, it is a widely used biochemical reference compound and is supplied strictly as a laboratory research material for metabolic and cell-signalling studies.

Research Background

AICAR has been investigated extensively as an activator of AMP-activated protein kinase (AMPK). Once phosphorylated intracellularly to its active nucleotide form (ZMP), it mimics elevated AMP levels and is studied for its capacity to engage the AMPK energy-sensing pathway. Research has examined AICAR in the context of cellular glucose uptake, mitochondrial biogenesis models, and metabolic-stress signalling, making it one of the most commonly referenced tools in energy-metabolism research.

In laboratory settings, AICAR is used as a benchmark AMPK agonist for comparative studies of metabolic regulation, cellular energetics, and signalling-pathway crosstalk. Its well-characterised mechanism and reproducible activity make it a standard reference in in vitro metabolic assays.

AICAR Specifications & Handling

• Purity: ≥99% by analytical assay.
• Verification: third-party HPLC and mass spectrometry, with a batch Certificate of Analysis (COA) available.
• Physical form: lyophilised powder.
• Storage: keep cool and dark; refrigerate or freeze for longer-term storage, protected from light and moisture.
• Reconstitution: sterile or bacteriostatic water is commonly used to prepare working stocks for in vitro assays; prepare only the quantity needed for the experiment.

Related Research Compounds

AICAR is frequently studied alongside other metabolic reference compounds such as MOTS-c and Adipotide, and cellular-regulation peptides such as Epithalon. Discover more in our research peptides range. This product is intended for laboratory research use only and is not for human or veterinary use.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.