MOTS-c

MOTS-c (mitochondrial open reading frame of the twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S ribosomal RNA gene. It is classified as a mitochondrial-derived peptide (MDP) and is supplied strictly as a laboratory research reference material for metabolic and cellular studies.

Research Background

MOTS-c has been investigated in the context of cellular energy homeostasis and metabolic signalling. Research has examined its reported influence on the AMP-activated protein kinase (AMPK) pathway and on folate-methionine metabolism, positioning it as a peptide of interest in studies of mitochondrial-nuclear communication. Investigators have also studied how MOTS-c distributes between the mitochondria and the nucleus under conditions of metabolic stress in model systems.

As one of the better-characterised mitochondrial-derived peptides, MOTS-c serves as a reference tool in laboratory work on cellular metabolism, exercise physiology models, and gene-expression regulation. Its compact sequence and defined origin make it a useful benchmark for comparative peptide research.

MOTS-c Specifications & Handling

• Purity: ≥99% by analytical assay.
• Verification: third-party HPLC and mass spectrometry, with a batch Certificate of Analysis (COA) available.
• Physical form: lyophilised powder.
• Storage: keep cool and dark; refrigerate or freeze for longer-term storage, away from light and moisture.
• Reconstitution: bacteriostatic or sterile water is commonly used to prepare working stocks for in vitro assays; reconstitute only the quantity needed.

Related Research Compounds

MOTS-c is often studied alongside metabolic reference compounds such as AICAR and Adipotide, and cellular-ageing peptides such as Epithalon. Discover more in our research peptides range. This product is intended for laboratory research use only and is not for human or veterinary use.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.