Mod GRF 1-29 (CJC-1295 No Dac)

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Mod GRF 1-29, commonly referred to as CJC-1295 without DAC, is a tetra-substituted analogue of the first 29 amino acids of growth hormone-releasing hormone (GHRH). It belongs to the class of GHRH-analogue peptides (growth hormone secretagogues) and is provided solely as a laboratory research reference material for endocrine and receptor studies.

Research Background

The parent GHRH(1-29) fragment retains the biologically active region of the full-length hormone. Mod GRF 1-29 incorporates four amino-acid substitutions intended to improve resistance to enzymatic degradation while preserving affinity for the GHRH receptor on pituitary somatotrophs. Research has examined how these substitutions extend stability in model systems relative to the unmodified fragment, without the extended albumin-binding half-life conferred by the DAC (drug affinity complex) modification found in other analogues.

In laboratory contexts, Mod GRF 1-29 is studied as a reference secretagogue for investigating GHRH-receptor signalling and its interaction with the somatotropic axis. It is frequently examined in combination studies with growth hormone-releasing peptides to explore synergistic receptor pathways in controlled in vitro settings.

Mod GRF 1-29 Specifications & Handling

Purity: ≥99% by analytical testing.
Verification: third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis (COA).
Physical form: lyophilised powder.
Storage: store cool and dark; refrigerate for near-term use and freeze for longer storage, protected from light and moisture.
Reconstitution: bacteriostatic water is typically used to prepare working solutions for laboratory assays; prepare only the amount required for immediate research.

Related Research Compounds

Researchers frequently compare Mod GRF 1-29 with CJC-1295 with DAC, the Sermorelin / Ipamorelin Blend, and GHRP-2. Explore the complete selection in our research peptides catalogue. This product is intended for laboratory research use only and is not for human or veterinary use.

Frequently Asked Questions

What is Mod GRF 1-29?

Mod GRF 1-29 (CJC-1295 without DAC) is a tetra-substituted analogue of GHRH(1-29), a GHRH-analogue peptide supplied only as a laboratory research reference material.

How does Mod GRF 1-29 differ from CJC-1295 with DAC?

It lacks the drug affinity complex (DAC) modification, so research has examined it as a shorter-acting GHRH analogue compared with the albumin-binding DAC version.

How is Mod GRF 1-29 tested?

Each batch undergoes third-party HPLC and mass spectrometry analysis, with a Certificate of Analysis (COA) confirming purity of at least 99%.

Is Mod GRF 1-29 for human use?

No. It is intended strictly for laboratory research use only and is not for human or veterinary use.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.