Adipotide

Adipotide, also known by its developmental designation FTPP (fat-targeted proapoptotic peptide), is a synthetic peptidomimetic assembled from two functional domains: a homing sequence linked to a proapoptotic effector motif. It is classified as a chimeric vascular-targeting peptide rather than a naturally occurring hormone, and is supplied strictly as a laboratory research reference material for in vitro and preclinical model work.

Research Background

Adipotide has been investigated in the context of the vasculature that supports white adipose tissue. Its targeting domain has been studied for affinity toward membrane markers such as prohibitin and annexin A2 that are reported on the endothelium associated with adipose depots. The second domain, a D-amino-acid proapoptotic sequence, is examined for its capacity to disrupt mitochondrial membranes once localised, a mechanism of interest to researchers modelling targeted, tissue-selective apoptosis.

Because of this two-part architecture, Adipotide is frequently used as a reference compound in studies of ligand-directed peptide delivery, endothelial targeting, and adipose-vascular biology. Research has examined how the homing motif influences selectivity and how conjugate design affects stability in model systems. It remains a tool for mechanistic and pharmacological investigation only.

Adipotide Specifications & Handling

• Purity: ≥99% as determined by analytical testing.
• Verification: third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis (COA) available.
• Physical form: lyophilised powder.
• Storage: keep cool and dark; refrigerate for short-term handling and freeze for longer-term storage, protected from light and moisture.
• Reconstitution: bacteriostatic or sterile water is typically used to prepare working solutions for laboratory assays; prepare only the quantity required for immediate research use.

Related Research Compounds

Researchers examining metabolic and mitochondrial pathways often reference Adipotide alongside MOTS-c and AICAR. You can explore the full range within our research peptides catalogue. This product is intended for laboratory research use only and is not for human or veterinary use.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.