Gonadorelin

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Gonadorelin refers to a synthetic decapeptide that functions as an analog of naturally occurring gonadotropin-releasing hormone (GnRH). Endogenous GnRH is produced by the hypothalamus. Plus, it plays a central role in regulating the hypothalamic-pituitary-gonadal (HPG) axis.

As a man-made peptide, Gonadorelin mimics the biological activity of natural GnRH. It does this by stimulating the anterior pituitary gland to release key reproductive hormones, including:

Luteinizing hormone (LH)
Follicle-stimulating hormone (FSH)

Because it is a synthetic analog, Gonadorelin is structurally designed to replicate the signaling activity of endogenous GnRH while being distinguishable from the naturally produced hormone.

Chemical and Molecular Properties

PubChem CID	638793
Molecular Formula	C55N75N17O13
Molecular Weight	1182.31g/mol
Synonyms	Gonadorelina GnRH-I 33515-09-2 Gonadorelinum
IUPAC	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS	33515-09-02
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store below 25°C
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanism of Action

Gonadorelin was observed to influence GnRH receptors. These are located in the anterior pituitary gland. Upon receptor binding, it stimulates the secretion of gonadotropins. These are primarily LH and FSH.

LH (Luteinizing Hormone): Involved in testosterone production in males and ovulation in females.
FSH (Follicle-Stimulating Hormone): Supports spermatogenesis in males and follicular development in females.

Research suggests that Gonadorelin may promote LH release more prominently under certain physiological conditions. However, both LH and FSH secretion are influenced through receptor activation.

Its receptor-mediated activity makes it a compound of interest in endocrine signaling research and pituitary function studies.

Potential Research Applications

In clinical and investigational settings, Gonadorelin has been explored for its role in evaluating and stimulating reproductive hormone pathways.

Research areas of interest include:

Assessment of pituitary gland function
Evaluation of LH and FSH secretion dynamics
Investigation of hypogonadotropic hypogonadism
Study of delayed puberty mechanisms
Controlled induction of ovulatory response in specific clinical contexts
Research into male reproductive hormone signaling and spermatogenic pathways

Because Gonadorelin directly stimulates the HPG axis, it is frequently utilized in diagnostic stimulation testing to evaluate pituitary responsiveness.

Gonadorelin in Reproductive Endocrine Research

Gonadorelin is utilized in laboratory investigations. In such a context, it has been examined for its effect on hypothalamic-pituitary-gonadal (HPG) axis signaling pathways. Through interaction with GnRH receptors in controlled experimental models, it is studied for its role in modulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion dynamics.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Frequently Asked Questions

What is Gonadorelin?

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH), a decapeptide used as a reference compound in endocrine laboratory research. PureRawz Australia supplies it strictly for in vitro and non-clinical work.

Is Gonadorelin legal or approved in Australia?

The Gonadorelin supplied here is not an approved therapeutic good and is not registered on the Australian Register of Therapeutic Goods for any use. It is offered for laboratory research use only, with the researcher responsible for TGA and Australian regulatory compliance.

How is Gonadorelin tested?

Each batch is characterised by third-party laboratories using HPLC and mass spectrometry to confirm identity and purity. A batch certificate of analysis (COA) reflecting purity of at least 99% is available for reference.

How does Gonadorelin differ from Triptorelin in research contexts?

Gonadorelin corresponds to the native GnRH decapeptide sequence, whereas Triptorelin is a modified GnRH analogue described in the literature as more metabolically stable. Both are handled solely as laboratory research reference peptides at PureRawz Australia.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.