PE-22-28
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PE-22-28 is a synthetic peptide derivative structurally related to spadin, a fragment associated with the sortilin pathway. It is characterized in biochemical research as a peptide investigated for its interaction with the TREK-1 (TWIK-related potassium channel 1) ion channel.
Current investigations primarily examine its interaction with ion channel signaling pathways and its influence on cellular electrophysiology under controlled laboratory conditions.
Chemical and Molecular Properties
| PE-22-28 | |
| PubChem CID | 172871876 |
| Molecular Formula | C35H59N11O11 |
| Molecular Weight | 833.9 g/mol |
| Synonyms | PE 22-28 (acetate) |
| IUPAC | acetic acid;(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| CAS | 1801959-12-5 |
| Labeling | Research-use peptide |
| Chemical Structure Depiction |  |
| Purity | Purity ≥95% (verified by HPLC or equivalent analytical method) |
| Classification | Research Use Only (RUO) |
| Storage Temperature | -20°C |
| Solubility | Soluble in aqueous buffers under controlled pH |
| Safety | For controlled laboratory handling only |
Proposed Working Mechanism of PE-22-28
PE-22-28 is being investigated for its interaction with TREK-1 potassium channels, which are part of the two-pore domain potassium (K2P) channel family. These channels contribute to the regulation of membrane potential and ion flux across cellular membranes. In controlled experimental systems, PE-22-28 has been reported to associate with TREK-1-related sites, with potential effects on potassium ion conductance and membrane polarization.
This interaction is being studied for its potential to modulate downstream signaling pathways linked to ion channel activity. In particular, changes in ion permeability and channel gating behavior are being studied for their potential to influence intracellular signaling cascades in controlled experimental systems.
Ongoing biochemical investigations also explore how TREK-1 modulation contributes to broader signaling network activity. These investigations include pathways related to ion homeostasis, membrane stability, and electrophysiological regulation under controlled experimental conditions.
Why Choose Purerawz for PE-22-28 Peptide?
Buy PE-22-28 peptide for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.
Note:
PE-22-28 peptide is an investigational compound. It is not established as safe or effective for any therapeutic use.
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
Frequently Asked Questions
What is PE-22-28?
PE-22-28 is a synthetic peptide derived from the neurotrophic peptide spadin, acting on the TREK-1 potassium channel. It is investigated in laboratory research on ion-channel modulation and neuronal signalling.
Is PE-22-28 legal or approved in Australia?
PE-22-28 is not an approved therapeutic good and does not appear on the Australian Register of Therapeutic Goods. It is offered strictly for laboratory research use only, not for human or veterinary use, and researchers must ensure compliance with all applicable Australian laws and TGA regulations.
How is PE-22-28 tested and quality assured?
Each batch of PE-22-28 is independently tested using HPLC and mass spectrometry to confirm identity and composition. A batch-specific Certificate of Analysis (COA) is provided, verifying purity of 99% or greater.
How should PE-22-28 be stored?
Lyophilised PE-22-28 is typically stored cool, dry and away from light, with freezer temperatures recommended for long-term storage. Researchers should follow the handling conditions stated on the accompanying COA.
For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.
| Strength | 8mg, 10mg |
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