FOXO4-DRI (Proxofim)

FOXO4-DRI, also referred to under the name Proxofim, is a synthetic D-retro-inverso (DRI) peptide derived from a fragment of the FOXO4 transcription factor. As a DRI analog it is assembled from D-amino acids in reversed sequence order, a design intended to improve proteolytic stability while preserving the interaction surface of interest. It is supplied strictly as laboratory reference material for research use only.

Research Background

FOXO4-DRI has been investigated in the context of the FOXO4-p53 protein-protein interaction, a pathway studied within cellular senescence research. The peptide is designed as a competitive element that engages this interaction interface, and much of the published interest concerns how disrupting the FOXO4-p53 association is studied in relation to senescent cell biology in vitro and in model systems.

Because it targets a transcription-factor interaction rather than a classical enzyme active site, FOXO4-DRI is frequently used as a tool compound in senescence, DNA-damage response and cell-fate signalling studies. The D-retro-inverso architecture is itself a subject of research interest, illustrating how backbone reversal and chirality inversion are applied to peptide-based interaction probes.

FOXO4-DRI Specifications & Handling

• Purity: ≥99% by analytical assessment.
• Analytical verification: independent third-party HPLC and mass spectrometry, accompanied by a batch certificate of analysis (COA).
• Composition: D-retro-inverso peptide (D-amino acids, reversed sequence) based on a FOXO4 fragment.
• Physical form: lyophilised powder.
• Storage: store cool and dark; protect from light and moisture, keeping lyophilised material sealed until use.
• Reconstitution: reconstitute with bacteriostatic water or a suitable research-grade solvent where applicable, according to the intended assay.
• Use restriction: for laboratory research use only; not for human or veterinary use.

Proxofim Specifications & Handling

For related tool-compound work, researchers often maintain complementary reference standards alongside FOXO4-DRI within their senescence and signalling libraries.

Related Research Compounds

Laboratories studying cellular ageing and peptide signalling may also reference Epithalon and Glutathione, or Thymalin for immune-ageing context. Explore additional reference materials in the research peptides category.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.