P21 (P021)

P21, also catalogued as P021, is a small peptidomimetic research compound derived from a biologically active region of ciliary neurotrophic factor (CNTF). It is designed as a stable, chemically modified analog and is supplied here strictly as laboratory reference material for research use only.

Research Background

P021 has been investigated in the context of neurotrophic signalling research, with particular interest in pathways associated with brain-derived neurotrophic factor (BDNF) signalling in preclinical model systems. As a CNTF-derived peptidomimetic, it is studied as a tool compound for probing neurotrophin-related mechanisms in vitro and in laboratory models of neuronal biology.

The compound’s design incorporates chemical modifications, including an adamantane group described in the literature, intended to improve stability and membrane permeability relative to the parent peptide fragment. This makes P021 of interest to researchers examining how peptidomimetic engineering influences the behaviour of neurotrophic-factor mimetics under experimental conditions.

P021 Specifications & Handling

• Purity: ≥99% by analytical assessment.
• Analytical verification: independent third-party HPLC and mass spectrometry, with a batch-specific certificate of analysis (COA) available.
• Classification: CNTF-derived peptidomimetic (small modified peptide analog).
• Physical form: lyophilised powder.
• Storage: store cool and dark; keep the lyophilised material sealed and protected from light and humidity.
• Reconstitution: reconstitute with an appropriate research-grade solvent or bacteriostatic water where applicable, guided by the compound’s solubility characteristics.
• Use restriction: for laboratory research use only; not for human or veterinary use.

Related Research Compounds

Laboratories studying neurotrophic and cognitive-signalling pathways may also reference Epithalon and MOTS-c as comparator research peptides, alongside Glutathione for redox-context studies. Browse further reference standards in the research peptides category.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.