MT-II

MT-II (Melanotan II) is a synthetic melanocortin receptor agonist peptide supplied as a research compound for laboratory investigation only. It is studied within the melanocortin signalling class and is not an approved therapeutic good in Australia. This listing is intended solely for qualified researchers requiring a well-characterised reference peptide for in-vitro and preclinical study.

Research Background

MT-II is a cyclic analogue investigated in laboratory research on the melanocortin receptor system, particularly its interaction with melanocortin receptor subtypes involved in pigmentation signalling and related physiological pathways. It is frequently used as a reference agonist in studies of melanocortin receptor binding and activation, where its stable cyclic structure supports reproducible characterisation of receptor engagement.

Preclinical and in-vitro research on MT-II typically examines receptor-selectivity profiles across the melanocortin receptor family, cyclic AMP signalling responses, and the structure-activity relationships that govern agonist potency. Its broad receptor engagement and structural stability make it a common comparator in melanocortin pharmacology research, where investigators explore how sequence and conformation influence binding affinity and functional selectivity in controlled model systems. The cyclic constraint of the molecule has made it a valuable tool for examining how conformational rigidity affects engagement across the several melanocortin receptor subtypes and the downstream signalling responses they produce. Its reproducible behaviour has made MT-II a frequent benchmark in reference panels, enabling investigators to calibrate assay sensitivity and confirm reproducibility across related melanocortin ligands. This established profile makes it a dependable reagent for method development and comparative receptor-profiling work within melanocortin research programmes.

MT-II Specifications & Handling

• Purity: ≥99% as determined by analytical testing
• Verification: independent third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis (COA) available for laboratory records
• Physical form: lyophilised white powder
• Storage: store the lyophilised peptide at -20°C, kept desiccated and protected from light for long-term stability
• Reconstitution: reconstitute in bacteriostatic or sterile water for laboratory handling; keep the reconstituted solution refrigerated at 2-8°C and use it within the working window generally recommended for peptide stability
• Handling: intended for use by qualified laboratory personnel using appropriate personal protective equipment in a suitable controlled environment
• Documentation: batch COA supplied on request to support internal verification and traceability records

Related Research Compounds

Researchers studying melanocortin and related peptide systems may also wish to reference Melanotan, Copper Peptide, and Pal-GHK, each of which is examined within adjacent peptide-signalling frameworks. Browse the full range of cosmetic peptides for additional reference materials and comparison compounds.

All peptides listed are supplied strictly for in-vitro and laboratory research use only. They are not intended for human or veterinary use, diagnosis, treatment, or any cosmetic application. Researchers are responsible for ensuring full compliance with applicable Australian law and Therapeutic Goods Administration (TGA) regulations governing research chemicals.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.