Melanotan

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Melanotan is a synthetic peptide modeled after the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH). This peptide was developed to support scientific investigations involving melanocortin signaling pathways and melanin production processes.

In controlled laboratory settings, researchers examine melanotan for its potential interaction with cellular mechanisms related to pigmentation and melanocyte activity. Because melanin plays a central role in pigmentation biology, melanotan has become a subject of interest in studies exploring pigment regulation and melanocortin receptor signaling.

Chemical and Molecular Properties

PubChem CID	92432
Molecular Formula	Melanotan I – C78H111N21O9 Melanotan II – C50H69N15O9
Molecular Weight	1024.2 g/mol
Synonyms	MT-II Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
IUPAC	(3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaaza cyclotricosane-23-carboxamide
CAS	121062-08-6
Labeling	Research Use Only (RUO), not for human or animal consumption
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store at -20°C (-4°F) for long-term stability
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanisms of Action

Within laboratory models, melanotan peptides are studied for their interaction with melanocortin receptors, particularly:

• MC1R (Melanocortin-1 Receptor)
• MC3R (Melanocortin-3 Receptor)
• MC4R (Melanocortin-4 Receptor)

Activation of these receptors in experimental systems has been associated with intracellular signaling pathways involved in melanin synthesis and melanocyte activity. Research models suggest that receptor activation may influence cellular processes related to pigmentation.

Melanotan II has also been investigated for broader melanocortin signaling interactions, including pathways associated with energy regulation and metabolic signaling in preclinical and experimental environments.

Potential Research Applications

Based on available scientific literature, melanotan peptides are studied in several areas of laboratory research:

Pigmentation and Melanin Studies

Researchers investigate how melanotan interacts with melanocortin receptors to influence melanin production in cellular and experimental models.

Ultraviolet (UV) Radiation Research

Experimental studies explore melanotan-related melanocortin signaling to better understand potential cellular responses to ultraviolet exposure.

Metabolic Signaling Research

Preclinical studies involving melanotan II examine melanocortin receptor pathways that may influence energy balance and metabolic signaling in laboratory models.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.