YK-11 (Myostine)
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YK-11 is a synthetic steroidal compound classified as a selective androgen receptor modulator (SARM). It is under investigation for its molecular interactions with androgen receptors and myostatin-related pathways. YK-11 is strictly for research use and is not approved for human or animal consumption.
Chemical and Molecular Properties
| YK-11 | |
| PubChem CID | 119058028 |
| Molecular Formula | C25H34O6 |
| Molecular Weight | 430.5 g/mol |
| Synonyms | YK-11 Z9748J6B0R UNII-Z9748J6B0R |
| IUPAC | (17β)-17-hydroxy-17-methylandrost-1,4-dien-3-one furan CAS: 431579-34-9 |
| CAS | 431579-34-9 |
| Labeling | Research Use Only (RUO), not for human or animal consumption. |
| Chemical Structure Depiction |
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| Purity | ≥98% |
| Classification | Research Use Only (RUO) |
| Storage Temperature | Lyophilized: –20 °C or colder |
| Solubility | DMSO, ethanol (research-grade solvents) |
| Safety | Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible |
YK‑11 Mechanism of Action
Androgen Receptor Interaction
YK‑11 binds to the androgen receptor (AR) and acts as a partial agonist, activating AR-mediated transcriptional signaling without promoting the full N‑terminal/C‑terminal (N/C) receptor interaction seen with potent endogenous agonists like dihydrotestosterone (DHT). This unique mode of receptor engagement appears to alter the conformational dynamics of AR and results in gene-selective transcriptional outcomes in cellular systems.
Regulation of Myogenesis & Follistatin Expression
In myoblast cell models (C2C12), YK‑11 stimulates the expression of myogenic regulatory factors (MRFs) such as MyoD, Myf5, and myogenin more significantly than DHT. It also uniquely induces follistatin (Fst) expression, a regulatory protein that antagonizes myostatin signaling—a pathway that normally suppresses muscle growth. Blocking Fst reverses the differentiation effects of YK‑11 in these cells, indicating Fst upregulation as a key component of its molecular effect.
Non‑Genomic Signaling and Osteoblastic Activity
Independent of classical genomic AR signaling, YK‑11 can activate non‑genomic pathways such as Akt signaling in osteoblastic cells. This activation has been associated with increased cell proliferation and bone‑specific differentiation markers (e.g., osteoprotegerin, osteocalcin), suggesting roles in skeletal cell biology that extend beyond traditional androgen receptor transcription.
Why Choose PureRawz for YK-11 (Myostine)?
Buy YK-11 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.
Note:
YK-11 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
Frequently Asked Questions
What is YK-11 (Myostine)?
YK-11, sometimes called Myostine, is a steroidal compound studied as a selective androgen receptor modulator in laboratory research. PureRawz Australia supplies it for laboratory research use only, not for human or veterinary use.
Is YK-11 (Myostine) legal or approved in Australia?
YK-11 is not an approved therapeutic good and is provided solely for laboratory research purposes. Researchers are responsible for ensuring their handling complies with TGA requirements and applicable Australian legislation.
How is YK-11 (Myostine) tested?
Batches are analysed by third-party laboratories using HPLC and mass spectrometry to confirm identity and a purity of at least 99%. These findings are documented on a batch-specific Certificate of Analysis (COA).
How should YK-11 (Myostine) be stored for research purposes?
This reference material is generally stored in a cool, dry, light-protected environment, following the conditions listed on the COA. Researchers should observe their own laboratory's storage and safety protocols.
For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.
| Form | Liquid, Tablets, Capsules, Powder, Injectables, Transdermal Liquid |
|---|---|
| Strength | 15ml/17mg per ml/250mg, 30ml/33mg per ml/1000mg, 30ml/67mg per ml/2000mg, 6mg/50ct/300mg, 6mg/100ct/600mg, 10mg/60ct/600mg, 60ml/17mg per ml/1000mg, 1g, 10ml/64mg per ml=640mg |
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