Andarine (S-4)

Andarine (S-4) is a non-steroidal research compound investigated within the selective androgen receptor modulator (SARM) class. It is supplied strictly for laboratory research use only and is not intended for human or veterinary use. This listing is provided solely for qualified researchers requiring a well-characterised reference material for in-vitro and preclinical study.

Research Background

Andarine is one of the earlier characterised SARMs studied in laboratory research on androgen receptor selectivity. Investigations have examined its partial-agonist behaviour at the androgen receptor and the tissue-selective binding characteristics that have established it as a common reference compound in structure-activity studies. As a member of the aryl-propionamide series, it has been used to explore how the molecular architecture of non-steroidal ligands governs receptor engagement.

In-vitro and preclinical research on Andarine has focused on receptor-binding assays, transcriptional reporter systems, and comparative profiling against other members of the aryl-propionamide SARM series. Its well-documented pharmacological behaviour makes it a frequently cited baseline in laboratory studies of non-steroidal androgen receptor ligands, where investigators examine binding affinity, functional selectivity, and the relationship between structural features and receptor activation in controlled model systems. Its partial-agonist character has made it a useful tool for probing how ligands can occupy the receptor while producing a graded transcriptional output relative to full agonists. As one of the most extensively documented compounds in its series, Andarine is often adopted as a benchmark against which newer analogues are compared, allowing researchers to calibrate assay performance and validate reproducibility across experiments. This established profile makes it a dependable reference reagent for method development within androgen-receptor research programmes.

Andarine (S-4) Specifications & Handling

• Purity: ≥99% as determined by analytical testing
• Verification: independent third-party HPLC and mass spectrometry, with a batch-specific Certificate of Analysis (COA) available for laboratory records
• Physical form: supplied as a laboratory-grade solution or fine powder depending on batch presentation
• Storage: store in a cool, dark environment away from heat and direct sunlight; refrigeration of solutions is recommended to preserve stability throughout the research period
• Handling: keep containers tightly sealed; handle using appropriate personal protective equipment in a suitable laboratory environment
• Documentation: batch COA available on request to support internal verification and traceability records

Related Research Compounds

Researchers examining androgen receptor selectivity may also wish to reference Ostarine (MK-2866), Ligandrol (LGD-4033), and S-23, each of which is studied within overlapping receptor-selectivity frameworks. Browse the wider range of research SARMs for additional reference materials and comparison compounds.

All SARMs listed are supplied strictly for in-vitro and laboratory research use only. They are not approved therapeutic goods and are not intended for human or veterinary use, diagnosis, treatment, or any performance or physique application. Researchers are responsible for ensuring full compliance with applicable Australian law and Therapeutic Goods Administration (TGA) regulations.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.