LGD-3303

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LGD-3303 is an investigational selective androgen receptor modulator (SARM) studied in experimental pharmacology and molecular signaling research. Compounds in the SARM class are evaluated in in vitro and biochemical systems to examine interactions with the androgen receptor (AR) and associated receptor-mediated transcriptional processes.

LGD-3303 is a nonsteroidal androgen receptor ligand designed to bind selectively to the AR while showing reduced binding affinity for other steroid hormone receptors in receptor-binding assays. This selective receptor-binding profile makes the compound suitable for laboratory investigations of androgen receptor signaling, receptor selectivity, and transcriptional regulation at the molecular level.

Chemical and Molecular Properties

LGD-3303
PubChem CID	25195253
Molecular Formula	C16H14ClF3N2O
Molecular Weight	342.74 g/mol
Synonyms	7N4E1X2RJM; 7H-Pyrrolo[3,2-f]quinolin-7-one, 9-chloro-2-ethyl-3,6-dihydro-1-methyl-3-(2,2,2-trifluoroethyl)-
IUPAC	9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-6H-pyrrolo[3,2-f]quinolin-7-one
CAS	917891-35-1
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	≥98%
Classification	Selective Androgen Receptor Modulator (SARM)
Storage Temperature	Store at −20 °C in a dry, light-protected environment
Solubility	Soluble in DMSO and other organic solvents; limited solubility in water
Safety	Handle using standard laboratory chemical safety procedures and PPE

Various Mechanisms of LGD–3303

Androgen Receptor (AR) Binding and Activation

In experimental models, LGD–3303 functions as a selective ligand of the androgen receptor (AR). Binding occurs at the receptor’s ligand-binding domain, inducing conformational changes that promote receptor activation and nuclear translocation.

Once localized in the nucleus, the activated receptor complex interacts with androgen response elements (AREs) within genomic regulatory regions. This interaction regulates transcriptional activity of AR-responsive genes in cellular signaling studies.

AR-Dependent Transcriptional Signaling

Activation of the AR by LGD–3303 has been examined in in vitro receptor assays and gene expression studies to evaluate transcriptional modulation associated with nuclear receptor signaling. These investigations focus on changes in AR-dependent transcriptional pathways and downstream intracellular signaling cascades in experimental cell models.

Why Choose PureRawz for LGD-3303?

Buy LGD–3303 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

LGD-3303 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

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For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.