Mazdutide

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Mazdutide, also known as IBI-362, is a synthetic dual-receptor agonist peptide studied in preclinical and laboratory research models. It is designed to activate two primary receptors:

GLP-1 receptor (GLP-1R)
Glucagon receptor (GCGR)

Mazdutide is an acylated peptide analogue with structural modifications intended to enhance stability and prolong its half-life in experimental settings. Researchers investigate Mazdutide to understand receptor activity and downstream cellular signaling in metabolic research models.

Chemical and Molecular Properties

PubChem CID	167312357
Molecular Formula	C207H317N45O65
Molecular Weight	4476 g/mol
Synonyms	IBI362 2259884-03-0 GTPL13924 IBI-362
IUPAC	20-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-2-methylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid
CAS	2259884-03-0
Labeling	Research Use Only (RUO), not for human or animal consumption
Chemical Structure Depiction
Purity	>95%
Classification	Research Use Only (RUO)
Storage Temperature	Store at -20°C (-4°F) for long-term stability
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanisms of Action

Mazdutide functions as a dual-receptor peptide agonist in controlled laboratory studies. Its primary actions are observed through:

GLP-1 Receptor (GLP-1R) Activation

Studied for effects on glucose-dependent cellular signaling in experimental models
Explored for modulation of nutrient absorption and energy-processing pathways in preclinical research

Glucagon Receptor (GCGR) Activation

Investigated for its influence on cellular energy regulation and metabolic signaling
Studied for coordinated receptor signaling networks in laboratory models

Potential Research Applications

Mazdutide is used in preclinical and laboratory research to study:

Receptor activation profiles: GLP-1R and GCGR signaling in experimental models
Intracellular signaling pathways: Mapping downstream pathways in controlled research systems
Metabolic pathway studies: Examining cellular energy regulation, glucose-dependent pathways, and receptor-mediated signaling networks
Preclinical model studies: Investigating potential interactions with cellular metabolic and endocrine pathways

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Frequently Asked Questions

What is Mazdutide?

Mazdutide is a peptide studied as a dual GLP-1 and glucagon receptor agonist in metabolic research. PureRawz Australia supplies it as a reference material for laboratory research use only, not for human or veterinary use.

Is Mazdutide legal or approved in Australia?

Mazdutide is not an approved therapeutic good in Australia and is offered strictly for laboratory research. The researcher is responsible for ensuring compliance with TGA regulations and all applicable Australian laws.

How is Mazdutide tested?

Each batch is characterised by third-party laboratories using HPLC and mass spectrometry to verify identity and a purity of at least 99%. A batch-specific Certificate of Analysis (COA) documents these results.

How should Mazdutide be stored for research purposes?

Peptide reference materials are typically stored refrigerated or frozen and protected from light, following the conditions listed on the COA. Researchers should observe their own laboratory's storage and handling procedures.

For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.