HBT1
AUD92
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HBT1 is a synthetic small-molecule compound under investigation as a research chemical. Researchers investigate its impact on glutamatergic receptor systems in conjunction with other substances.
The compound is chemically defined and characterized by its distinct molecular structure, which includes a pyrazole and benzothiophene core. HBT1 is supplied exclusively for research purposes and has not been approved for human or animal use. Its well-defined chemical identity and purity make it suitable for in vitro and preclinical investigations into receptor pharmacology and signaling pathways.
Chemical and Molecular Properties
| HBT1 | |
| PubChem CID | 1222102 |
| Molecular Formula | C16H17F3N4O2S |
| Molecular Weight | 386.4 g/mol |
| Synonyms | RefChem: 908944 |
| IUPAC | 2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
| CAS | 489408-02-8 |
| Labeling | Research Use Only (RUO), not for human or animal consumption. |
| Chemical Structure Depiction |
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| Purity | ≥98% |
| Classification | Research Use Only (RUO) |
| Storage Temperature | Store at −20 °C in a dry, light-protected environment |
| Solubility | DMSO and other research-grade organic solvents |
| Safety | Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible |
HBT1 Working Mechanism
AMPA Receptor Positive Allosteric Modulation
HBT1 mediates fast excitatory neurotransmission by acting as a positive allosteric modulator (PAM) of AMPA receptors, which are ionotropic glutamate receptors. In the receptor’s ligand-binding domain (LBD), the chemical attaches to an allosteric site instead of the active glutamate-binding site.
Glutamate-mediated signaling is improved in experimental models by this binding, which stabilizes receptor conformations that promote channel opening in the presence of endogenous glutamate.
Glutamate-Dependent Receptor Potentiation
In in vitro electrophysiology studies, HBT1 demonstrates glutamate-dependent potentiation, meaning that receptor activity is enhanced only during ligand binding. This property reduces intrinsic agonistic activity while still promoting receptor signaling, allowing for the study of ion channel conductance and calcium influx in cellular models.
Modulation of Neurotrophic Signaling Pathways
HBT1’s potentiation of AMPA receptors can affect intracellular signaling cascades linked to the expression of brain-derived neurotrophic factor (BDNF). The effects of allosteric modulation on intracellular calcium signaling and downstream transcriptional pathways have been investigated in studies employing neuronal cells. HBT1’s low intrinsic agonistic activity has been investigated as a tool for mechanistic research into receptor-mediated synaptic signaling without producing overstimulation artifacts observed with some other AMPA modulators.
Why Choose Purerawz for HBT1?
Buy HBT1 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.
Note:
HBT1 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use
Research Applications of HBT1
HBT1 is used exclusively as a research tool in preclinical and experimental models. Its primary applications include:
- AMPA Receptor Pharmacology – Studying allosteric modulation in binding assays and electrophysiology.
- Synaptic Signaling and Plasticity – Investigating excitatory neurotransmission and long-term potentiation pathways.
- Neurotrophic Signaling—Examining BDNF-related transcriptional pathways and calcium-dependent intracellular signaling.
- Molecular Pharmacology—Serving as a reference compound for characterizing next-generation AMPA receptor modulators.
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
Frequently Asked Questions
What is HBT1?
HBT1 is a synthetic research compound investigated in relation to neurotrophic signalling pathways in laboratory studies. It is supplied strictly as a research chemical for laboratory investigation and is not for human or veterinary use.
Can HBT1 be imported or is it legal in Australia?
HBT1 is offered for laboratory research use only, and novel synthetic compounds in this class may be subject to import or supply restrictions in Australia. Researchers must confirm the current regulatory and import status with the relevant authorities before ordering or importing.
How is HBT1 tested?
Each batch is analysed by independent third-party laboratories using high-performance liquid chromatography (HPLC) and mass spectrometry. A batch-specific certificate of analysis (COA) documents identity and a purity specification of not less than 99%.
How should HBT1 be stored in a laboratory setting?
For research stability it is typically kept in a cool, dry place, protected from light and moisture, with the container tightly sealed. Storage should follow the conditions stated on the accompanying certificate of analysis.
For laboratory and research use only. This product is not for human or veterinary consumption, and nothing on this page is medical advice. Researchers are responsible for compliance with all applicable Australian laws (including TGA regulations) and institutional guidelines.
| Form | Powder |
|---|---|
| Strength | 1g |
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