NSI 189 Phosphate

Buy NSI 189 Phosphate online | NSI 189 Phosphate for sale

NSI 189 is a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and neurogenesis in the murine hippocampus in vivo.

The chemical is an experimental antidepressant that is considered not safe for human consumption or household use.

PureRawz sells NSI 189 phosphate for laboratory research use only. Our stock of this compound is not recommended for human ingestion, even veterinary use, since its expected medical application is still under review. Purchase NSI 189 phosphate for research purposes only.

What is NSI 189 Phosphate?

NSI 189 phosphate is a novel neurogenic compound that acquires pleiotropic properties.

Emerging evidence also suggests NSI 189 phosphate powder has regionally specific effects, with neurogenesis occurring primarily in the hippocampus’s subventricular zone.

According to preliminary findings from a proof-of-concept study, NSI 189 may be capable of alleviating depressive symptoms and improving cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD).

It is an antidepressant and neurogenic substance that can enhance cognition and treat traumatic brain injury, Alzheimer’s disease (AD), post-traumatic stress disorder (PTSD), and stroke. It can also prevent cognitive and memory deterioration with aging.

Possible Applications of NSI 189 Phosphate

The FDA has not authorized NSI-189 as an investigational medication. This compound’s safety and effectiveness are uncertain. Applications below describe the exploratory uses of NSI-189, although insufficient data supports its usage for any of these illnesses.

NSI 189 Phosphate and Cognitive Impairment

Phase I and II clinical trials that examined depression also identified possible advantages for cognition.

The 40 mg dose was also linked to self-reported cognition enhancements, including memory, working memory, and executive function, in the phase II trial of 220 participants.

NSI 189 Phosphate and Major Depressive Disorder (MDD)

Twenty-four MDD patients were recruited, and their severity and conditions prior to recruitment were confirmed via remote interviews. Eligible patients were given NSI-189 or a placebo for 28 days in an inpatient setting, with safety, pharmacokinetics (PK), and efficacy evaluated. Outpatient follow-up visits continued until day 84. NSI-189 was well tolerated at all doses, with no severe side effects.

NSI 189 Phosphate and Ischemic Stroke

In adult Sprague-Dawley rats, oral administration of NSI-189 beginning at 6 hours after middle cerebral artery occlusion and continuing every day for the following 12 weeks led to a significant improvement in stroke-induced motor and neurological deficits, which was maintained up to 24 weeks post-stroke.

NSI 189 Phosphate and Diabetic Neuropathy

Oral administration of NSI-189 to male and female murine models of type 1 and type 2 diabetes prevented numerous functional and structural indicators of small and large fiber peripheral neuropathy, increased hippocampal neurogenesis, synaptic markers, volume, and safeguarded long-term memory.

Mechanisms of Action

NSI-189’s mechanism of action is not fully understood. According to laboratory research, this experimental compound may work by promoting neurogenesis or the formation of new nerve and brain cells.

NSI-189 appears to have the greatest effect on the hippocampus, the part of the brain responsible for emotion, learning, and memory.

NSI-189 phosphate for sale stimulated neurogenesis in human cells derived from the hippocampus in a cell study. A mouse study suggests that NSI-189 may promote neurogenesis in the hippocampus.